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Diseases

Genetic and Rare Diseases Information Center (GARD)

Pulmonary arteriovenous malformation


Other Names for this Disease
  • PAVM
  • Pulmonary arteriovenous fistula
  • Pulmonary AVM
  • Arteriovenous malformation, pulmonary
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Overview

Pulmonary arteriovenous malformation (PAVM) is a condition that affects blood flow between the heart and the lungs. Affected people have an abnormal connection between the pulmonary vein (carries blood from the lungs to the heart) and pulmonary artery (carries blood from the heart to the lungs). As a result, blood may not be properly oxygenated by the lungs. Some affected people may have no signs or symptoms of the condition. When present, symptoms may include difficulty breathing, nosebleeds, shortness of breath, difficulty exercising, and blue skin. Most people with PAVM have an inherited condition called hereditary hemorrhagic telangiectasia, which is inherited in an autosomal dominant manner. Other conditions that are less commonly associated with PAVM include liver disease (mainly liver cirrhosis), certain forms of congenital heart disease, chronic infections, and metastatic thyroid cancer. Treatment varies based on the severity of the condition and the associated signs and symptoms. When necessary, treatment typically includes embolization, surgery, and/or addressing associated conditions.[1][2][3]
Last updated: 5/25/2016

References

  1. Shovlin CL. Pulmonary arteriovenous malformations. Am J Respir Crit Care Med. December 2014; 190(11):1217-1228.
  2. Barry A Love, MD. Pulmonary Arteriovenous Fistulae. Medscape Reference. January 2015; http://emedicine.medscape.com/article/900681-overview.
  3. Pulmonary arteriovenous fistula. MedlinePlus. August 2014; https://www.nlm.nih.gov/medlineplus/ency/article/001090.htm.
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Basic Information

  • MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Pulmonary arteriovenous malformation. Click on the link to view a sample search on this topic.

Selected Full-Text Journal Articles

Other Names for this Disease
  • PAVM
  • Pulmonary arteriovenous fistula
  • Pulmonary AVM
  • Arteriovenous malformation, pulmonary
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.