- Chronic Ataxic Neuropathy Ophthalmoplegia M-protein Agglutination Disialosyl antibodies syndrome
- Chronic sensory ataxic neuropathy with anti-disialosyl antibodies
Your QuestionI have had a very hard time finding information on CANOMAD. A loved one has had this condition for 4 years. I would like to learn more about it.
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Questions on this page
- What is CANOMAD syndrome?
- Are there any medical terms that I should review prior to reading information about CANOMAD syndrome?
- Why is there such limited information on CANOMAD syndrome?
- What symptoms have been observed in patients with CANOMAD syndrome?
- What causes CANOMAD syndrome?
- How might CANOMAD syndrome be treated?
(C)hronic - refers to the long duration of the condition.
(A)taxic - relates to the loss of ability to coordinate muscular movement.
(N)europathy - describes a disease or abnormality of the nervous system, especially one affecting the cranial or spinal nerves.
(O)phthalmoplegia - refers to the paralysis of one or more of the muscles of the eye.
Ig(M) paraprotein - IgM is a protein, more specifically an antibody, that is secreted by plasma cells. Plasma cells are a pale yellow mixture of water, proteins and salts. One of the functions of plasma is to act as a carrier for blood cells, nutrients, enzymes and hormones. In CANOMAD the IgM antibody is abnormally present. The term “paraprotein” actually refers to any abnormal plasma protein associated with a disease.
Cold (A)gglutinins - antibodies that are active at cold temperatures, attaching to red blood cells and causing the red cells to bind together or 'agglutinate.'
(D)isialosyl antibodies - in this disease, "anti-disialosyl antibodies" refers to the IgM antibodies.
The majority of the cases studied (16 out of the 18) also had motor and sensory cranial nerve involvement, causing paralysis of some of the eye muscles (ophthalmoplegia), difficulty swallowing, difficulty articulating words and, rarely, respiratory muscle weakness. These symptoms were constant in some people, but for others the symptoms came and went.
In general, CANOMAD syndrome tends to have a chronic course that often extends over decades.
- Willison, HJ et. al.,. The clinical and laboratory features of chronic sensory ataxic neuropathy with anti-disialosyl IgM antibodies. Brain. 2001 Oct; 124(Pt 10):1968-77. http://brain.oxfordjournals.org/content/124/10/1968.long.
- Scheinfeld NS. Intravenous Immunoglobulin. Medscape Reference. February 3, 2016; http://emedicine.medscape.com/article/210367-overview.
- Arbogast SD, Khanna S, Koontz DW, Tomsak RL, Katirji B, Leigh RJ. Chronic ataxic neuropathy mimicking dorsal midbrain syndrome. J Neurol Neurosurg Psychiatry. 2007 Nov; 78(11):1276-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117616/.
- Relapsing sensorimotor neuropathy with ophthalmoplegia, antidisialosyl antibodies, and extramembranous glomerulonephritis. Delval A, Stojkovic T, Vermersch P. Muscle Nerve. 2006 Feb; 33(2):274-7. https://www.ncbi.nlm.nih.gov/pubmed/?term=16258949.
- Fontaine B. CANOMAD syndrome. Orphanet. March 2007; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=71279.
- Johnson K, Malkan A, Shaffi M. Facial Involuntary Movements and Respiratory Failure in CANOMAD, Responsive to IVIG Therapy. Case Rep Med. 2015; 2015:170543. http://www.hindawi.com/journals/crim/2015/170543/.
- Krenn M, Keir G, Wieshmann UC. CANOMAD responding to weekly treatment with intravenous immunoglobulin (IVIg). BMJ Case Rep. 2014 Apr 10; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987528/.