Other Names for this Disease
- Chronic Ataxic Neuropathy Ophthalmoplegia M-protein Agglutination Disialosyl antibodies syndrome
- Chronic sensory ataxic neuropathy with anti-disialosyl antibodies
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Oral or intravenous corticosteroids, ß-interferons, intravenous immunoglobulin (IVIG), plasma exchange, and cytotoxic drugs and a combination of these therapies have all been used in treating CANOMAD syndrome with varying success. Their use, however, has not been evaluated systematically. In recent years, IVIG seems to be the preferred method of treatment.
Last updated: 4/18/2016
- Willison, HJ et. al.,. The clinical and laboratory features of chronic sensory ataxic neuropathy with anti-disialosyl IgM antibodies. Brain. 2001 Oct; 124(Pt 10):1968-77. http://brain.oxfordjournals.org/content/124/10/1968.long.
- Scheinfeld NS. Intravenous Immunoglobulin. Medscape Reference. February 3, 2016; http://emedicine.medscape.com/article/210367-overview.
- Arbogast SD, Khanna S, Koontz DW, Tomsak RL, Katirji B, Leigh RJ. Chronic ataxic neuropathy mimicking dorsal midbrain syndrome. J Neurol Neurosurg Psychiatry. 2007 Nov; 78(11):1276-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117616/.
- Relapsing sensorimotor neuropathy with ophthalmoplegia, antidisialosyl antibodies, and extramembranous glomerulonephritis. Delval A, Stojkovic T, Vermersch P. Muscle Nerve. 2006 Feb; 33(2):274-7. https://www.ncbi.nlm.nih.gov/pubmed/?term=16258949.
- Fontaine B. CANOMAD syndrome. Orphanet. March 2007; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=71279.
- Johnson K, Malkan A, Shaffi M. Facial Involuntary Movements and Respiratory Failure in CANOMAD, Responsive to IVIG Therapy. Case Rep Med. 2015; 2015:170543. http://www.hindawi.com/journals/crim/2015/170543/.
- Krenn M, Keir G, Wieshmann UC. CANOMAD responding to weekly treatment with intravenous immunoglobulin (IVIg). BMJ Case Rep. 2014 Apr 10; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987528/.
- The U.S. National Institutes of Health, through the National Library of Medicine, developed ClinicalTrials.gov to provide patients, family members, and members of the public with current information on clinical research studies. There is a study titled Diagnosis and History Study of Patients With Different Neurological Conditions which may be of interest to you. To find this trial, click on the link above.