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Diseases

Genetic and Rare Diseases Information Center (GARD)

Lymphatic malformations


Other Names for this Disease
  • Lymphangiomas
Related Diseases
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Overview

Lymphatic malformations or lymphangiomas are benign (non-cancerous) vascular lesions made of fluid-filled spaces (cysts) thought to occur due to abnormal development of the lymphatic system.[1]  They are classified as cystic hygroma, lymphangioma circumscriptum and cavernous lymphangioma.[2][3] They are present at birth, although they may be discovered later in life.[4] They are most commonly located in the neck and axilla, but they also occur in the mouth, arm, mediastinum, lung, abdomen and viscera. Some may appear as a tiny blue or red spot while others are massive and affect an entire arm or leg.[8019[11746] The signs and symptoms vary depending on the size and location of the mass; however, lymphangiomas can disfigure affected areas and disrupt the function of nearby organs or tissues.[1] The exact underlying cause is unknown. Treatment options vary based on the signs and symptoms present in each person but may include surgery.[3]
Last updated: 6/22/2016

References

  1. Lymphatic Malformations. NORD. June 2011; https://www.rarediseases.org/rare-disease-information/rare-diseases/byID/646/viewAbstract.
  2. Pielop JA. Vascular lesions in the newborn. UpToDate. May, 2016; http://www.uptodate.com/contents/vascular-lesions-in-the-newborn.
  3. Robert A Schwartz, MD, MPH. Lymphangioma. Medscape Reference. 2016; http://emedicine.medscape.com/article/1086806-overview.
  4. Lymphatic malformation. DermNet NZ. December 2014; http://dermnetnz.org/vascular/lymphangioma.html.
  5. Luo CC, Huang CS, Chao HC, Chu SM & Hsueh C. Intra-Abdominal Cystic Lymphangiomas in Infancy And Childhood. Chang Gung Med J. July, 2004; 27(7):http://memo.cgu.edu.tw/cgmj/2707/270704.pdf.
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Basic Information

  • DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
  • The National Organization for Rare Disorders (NORD) is a federation of more than 130 nonprofit voluntary health organizations serving people with rare disorders. Click on the link to view information on this topic.

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Lymphatic malformations. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Lymphangiomas
Related Diseases
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.