Intrahepatic cholestasis of pregnancy
Other Names for this Disease
- Familial intrahepatic cholestasis of pregnancy
- Recurrent intrahepatic cholestasis of pregnancy
- Pregnancy related cholestasis
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bile (a digestive juice) from liver cells. The bile then builds up in the liver, impairing liver function. Symptoms typically become apparent in the third trimester of pregnancy and can include severe itching (pruritus). Occasionally, the skin and the whites of the eyes can have a yellow appearance (jaundice). ICP is additionally associated with risks to the developing baby such as premature delivery and stillbirth. The cause of ICP is largely unknown, although approximately 15% of cases are caused by mutations in either the ABCB11 or ABCB4 genes. Mutations within the ABCB11 and ABCB4 genes are inherited in an autosomal dominant manner. Symptoms of ICP are typically limited to pregnancy. Bile flow returns to normal after delivery and the signs and symptoms of the condition disappear, however, they can return during later pregnancies.Intrahepatic cholestasis of pregnancy (ICP) is a disorder of the liver that occurs in women during pregnancy. Cholestasis is a condition that impairs the release of
Last updated: 3/15/2016
- Intrahepatic cholestasis of pregnancy. Genetics Home Reference. May 2015; https://ghr.nlm.nih.gov/condition/intrahepatic-cholestasis-of-pregnancy.
- Rigby FB. Intrahepatic Cholestasis of Pregnancy. Medscape. February 24, 2016; http://emedicine.medscape.com/article/1562288-overview.
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Intrahepatic cholestasis of pregnancy type 1
Intrahepatic cholestasis of pregnancy type 3
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