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Diseases

Genetic and Rare Diseases Information Center (GARD)

Vibratory urticaria


Other Names for this Disease
  • Angioedema, vibratory
  • Vibratory angioedema
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Overview

Vibratory urticaria is a rare condition that is characterized by itching, reddish skin and swelling within minutes of local exposure to vibration. Areas of skin that are most exposed to the stimulus (often the hands) are generally more severely affected. People with this condition may also experience flushing, headaches, fatigue, blurry vision or a metallic taste in the mouth during episodes of skin involvement.[1][2][3] Common triggers include mowing the lawn, riding a motorcycle, horseback riding, or mountain biking.[1] Vibratory urticaria is caused by changes (mutations) in the ADGRE2 gene and appears to be inherited in an autosomal dominant manner. Treatment involves avoiding vibration stimulus and use of antihistamines.[3]
Last updated: 7/20/2016

References

  1. Dice JP & Gonzalez-Reyes E. Physical urticarias. UpToDate. January 25, 2016; http://www.uptodate.com/contents/physical-urticarias.
  2. Schoepke N, Doumoulakis G & Maurer M. Diagnosis of urticaria. Indian J Dermatol. May-June, 2013; 58(3):211–218. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667285/.
  3. NIH Scientists Discover Genetic Cause of Rare Allergy to Vibration. National Institute of Allergy and Infectious Diseases. February 3, 2016; http://www.niaid.nih.gov/news/newsreleases/2016/Pages/VibratoryUrticaria.aspx.
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Basic Information

In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Vibratory urticaria. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Angioedema, vibratory
  • Vibratory angioedema
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.