- Juvenile pilocytic astrocytoma
Your QuestionMy grandson was recently diagnosed with pilocytic astrocytoma. He was operated on successfully this year. No further treatment necessary, just follow up with the neurosurgeon for 5 years. Is this a hereditary condition? He has an 18 year old sister, and we want to know if she should be tested.
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Although most individuals with a pilocytic astrocytoma do not have an underlying genetic condition, astrocytomas have been associated with a few "predisposing" genetic syndromes. Individuals with these syndromes will not necessarily develop one; these tumors just occur with a greater frequency in affected individuals. Genetic syndromes in which astrocytomas have been reported to occur include:
All of these genetic conditions follow an autosomal dominant pattern of inheritance. Individuals who are interested in learning about personal genetic risks for these conditions and/or genetic testing options for themselves or family members should speak with a genetics professional.
- General Information About Adult Brain Tumors. National Cancer Institute (NCI). July 2011; http://www.cancer.gov/cancertopics/pdq/treatment/adultbrain/Patient#Keypoint5. Accessed 9/16/2011.
- Juvenile Pilocytic Astrocytoma. National Organization for Rare Disorders (NORD). 2007; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/775/viewAbstract. Accessed 9/15/2011.
- Pilocytic Astrocytoma. National Brain Tumor Society. 2013; http://www.braintumor.org/patients-family-friends/about-brain-tumors/tumor-types/pilocytic-astrocytoma.html. Accessed 8/9/2013.
- Juvenile Pilocytic Astrocytoma. NORD. 2007; http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/1194/viewAbstract. Accessed 8/9/2013.
- Jacques Grill. Astrocytoma. Orphanet. November 2007; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=94. Accessed 8/14/2013.