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Diseases

Genetic and Rare Diseases Information Center (GARD)

Large granular lymphocyte leukemia


Other Names for this Disease
  • LGL leukemia
  • T-cell large granular lymphocyte leukemia
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Overview

Large granular lymphocyte (LGL) leukemia is a rare cancer of a type of white blood cells called lymphocytes. LGL leukemia causes a slow increase in white blood cells called T lymphocytes, or T cells, which originate in the lymph system and bone marrow and help to fight infection. This disease usually affects people in their sixties. Symptoms include anemia; low levels of platelets (thrombocytopenia) and infection-fighting neutrophils (neutropenia) in the blood; and an enlarged spleen. About one-third of patients are asymptomatic at the time of diagnosis. The exact cause of LGL leukemia is unknown. Doctors can diagnose this disease through a bone marrow biopsy, or by using a specialized technique in which various types of blood or bone marrow cells are separated, identified, and counted.[1]
Last updated: 8/2/2011

References

  1. T-cell large granular lymphocyte leukemia. Orphanet. May 2007; http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Expert=86872&lng=EN. Accessed 8/2/2011.
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In Depth Information

  • The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Large granular lymphocyte leukemia. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • LGL leukemia
  • T-cell large granular lymphocyte leukemia
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.