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Genetic and Rare Diseases Information Center (GARD)

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Lennox-Gastaut syndrome


Other Names for this Disease
  • Encephalopathy of childhood
  • Epileptic encephalopathy Lennox-Gastaut type
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Overview

Lennox-Gastaut syndrome is a form of severe epilepsy that begins in childhood. It is characterized by multiple types of seizures and intellectual disability.[1] This condition can be caused by brain malformations, perinatal asphyxia (lack of oxygen), severe head injury, central nervous system infection and inherited degenerative or metabolic conditions. In about one-third of cases, no cause can be found.[1][2] Treatment for Lennox-Gastaut syndrome includes anti-epileptic medications such as valproate, lamotrigine, felbamate, or topiramate. There is usually no single antiepileptic medication that will control seizures. Children may improve initially, but many later show tolerance to a drug or develop uncontrollable seizures.[2]
Last updated: 9/17/2013

References

  1. Lennox-Gastaut syndrome. Genetics Home Reference (GHR). July 2010; http://ghr.nlm.nih.gov/condition/lennox-gastaut-syndrome. Accessed 9/17/2013.
  2. NINDS Lennox-Gastaut Syndrome Information Page. National Institute of Neurological Disorders and Stroke (NINDS). July 31, 2013; http://www.ninds.nih.gov/disorders/lennoxgastautsyndrome/lennoxgastautsyndrome.htm. Accessed 9/17/2013.
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Basic Information

In Depth Information

  • Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
  • Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. Each entry has a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine. 
  • Orphanet is a European reference portal for information on rare diseases and orphan drugs.  Access to this database is free of charge.
  • PubMed is a searchable database of medical literature and lists journal articles that discuss Lennox-Gastaut syndrome. Click on the link to view a sample search on this topic.
Other Names for this Disease
  • Encephalopathy of childhood
  • Epileptic encephalopathy Lennox-Gastaut type
See Disclaimer regarding information on this site. Some links on this page may take you to organizations outside of the National Institutes of Health.