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Eosinophil-Associated Disease: Approaches to Treatment

Wednesday, May 25, 2005 - Thursday, May 26, 2005
University Hospital, Bern, Switzerland

Idiopathic hypereosinophilic syndromes (HESs), including idiopathic HES, familial hypereosinophilia, Churg-Strauss vasculitis, and eosinophil-associated gastrointestinal disorders (EGID), are a heterogeneous group of rare disorders that are characterized by marked eosinophilia in the peripheral blood and/or tissues without identifiable cause. The goals of this conference were to bring together clinicians and scientists with expertise in the treatment of the various idiopathic hypereosinophilic disorders in order to summarize and discuss available data on efficacy and side effects of the therapeutic agents and modalities currently in use for the treatment of selected HESs, with the goal of identifying a consensus approach; to identify novel agents and/or strategies for use in future clinical trials; and to continue to expand the consortium of clinical researchers and available resources for collaborative study established at the prior workshop on the diagnosis of eosinophilic disorders in order to foster the development of multicenter protocols to study the pathogenesis and treatment of idiopathic hypereosinophilic disorders. Participants addressed the state of currently available therapies for three idiopathic HESs, taking into account recent developments in diagnostic testing, advances in the understanding of the pathogenesis of hypereosinophilic conditions, and novel strategies for the treatment of idiopathic eosinophilic disorders.

Amy Klion, M.D., (301) 435-8903,

Co-funding Institute(s):
National Institute of Allergy and Infectious Diseases

From the National Center for Advancing Translational Sciences

From the National Institutes of Health

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