This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
Wide foot[ more ]
Increased width of the forehead
Wide forehead[ more ]
|Coarse facial features||
Coarse facial appearance
|Cortical diaphyseal thickening of the upper limbs||0003859|
|Deep palmar crease||
Deep palm line
|Deep plantar creases||
Deep wrinkles in soles of feet
Tiredness[ more ]
Increased size of cheeks
Large cheeks[ more ]
|Growth hormone excess||0000845|
Sweating, increased[ more ]
Elongation of face
Increased height of face
Increased length of face
Vertical elongation of face
Vertical enlargement of face
Vertical overgrowth of face[ more ]
Abnormally large tongue
Increased size of tongue
Large tongue[ more ]
Big lower jaw
Increased projection of lower jaw
Increased size of lower jaw
Large lower jaw
Prominent lower jaw[ more ]
Degenerative joint disease
|Pituitary growth hormone
Increased body height
Tapering fingers[ more ]
|Thick lower lip vermilion||
Increased volume of lower lip
Plump lower lip
Prominent lower lip[ more ]
Increased breadth of nose
Increased nasal breadth
Increased nasal width
Increased width of nose[ more ]
|30%-79% of people have these symptoms|
|Abnormal fingernail morphology||
Abnormality of the fingernails[ more ]
|Abnormal toenail morphology||
Abnormality of the toenail
Abnormality of the toenails[ more ]
Excessive, persistent worry and fear
Broad lower face
Wide jaw[ more ]
Excessive hairiness over body
Husky voice[ more ]
Round back[ more ]
Intermittent migraine headaches
Migraine headaches[ more ]
Fullness of eyelids
Swelling of eyelids[ more ]
Pins and needles feeling
Tingling[ more ]
Pauses in breathing while sleeping
|Spinal canal stenosis||
Narrow spinal canal
Unibrow[ more ]
|Widely spaced teeth||
Widely-spaced teeth[ more ]
|5%-29% of people have these symptoms|
Darkened and thickened skin
Painful or difficult urination
Spontaneous milk flow from breast
Enlarged and thickened heart muscle
Difficulty getting a full erection
Difficulty getting an erection[ more ]
|Pituitary prolactin cell adenoma||0006767|
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If you need medical advice, you can look for doctors or other healthcare professionals who have experience with this disease. You may find these specialists through advocacy organizations, clinical trials, or articles published in medical journals. You may also want to contact a university or tertiary medical center in your area, because these centers tend to see more complex cases and have the latest technology and treatments.
If you can’t find a specialist in your local area, try contacting national or international specialists. They may be able to refer you to someone they know through conferences or research efforts. Some specialists may be willing to consult with you or your local doctors over the phone or by email if you can't travel to them for care.
You can find more tips in our guide, How to Find a Disease Specialist. We also encourage you to explore the rest of this page to find resources that can help you find specialists.
Related diseases are conditions that have similar signs and symptoms. A health care provider may consider these conditions in the table below when making a diagnosis. Please note that the table may not include all the possible conditions related to this disease.
Conditions with similar signs and symptoms from Orphanet
Differential diagnosis includes other causes of acromegaly (FIPA, MEN1, Carney complex and XLAG) as well as pachydermoperiostosis and acromegaloid features of severe insulin resistance.
Visit the Orphanet disease page for more information.
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know.