This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
|Chronic otitis media||0000389|
Decreased immune function
Decreased blood lymphocyte number
|30%-79% of people have these symptoms|
|Elevated hepatic transaminases||
High liver enzymes
Increased spleen size
|5%-29% of people have these symptoms|
|Failure to thrive in infancy||
Faltering weight in infancy
Weight faltering in infancy[ more ]
|Posterior pharyngeal cleft||0006783|
|Restrictive ventilatory defect||0002091|
|Percent of people who have these symptoms is not available through HPO|
Low B cell count
|Recurrent bacterial infections||
Bacterial infections, recurrent
Frequent bacterial infections
Increased susceptibility to bacterial infections
Recurrent major bacterial infections[ more ]
|Recurrent otitis media||
Recurrent middle ear infection
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Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Living with a genetic or rare disease can impact the daily lives of patients and families. These resources can help families navigate various aspects of living with a rare disease.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Got a Great Research Idea? ‘All of Us’ Wants to Hear It!
January 18, 2018
New NCATS Rare Diseases Research Video
December 27, 2017
Rare Disease Day at NIH on March 1, 2018
December 19, 2017
Questions sent to GARD may be posted here if the information could be helpful to others. We remove all identifying information when posting a question to protect your privacy. If you do not want your question posted, please let us know. Submit a new question
I have CVID and I am currently expecting my second child. I breastfed my first for 6 months, however, this was before my diagnosis. Is it worth me feeding a second time? Will the Ig from my replacement therapy be passed on to my child in my milk, or would they get more nutrition with formula milk? See answer
My daughter was diagnosed late at 38 and she is now almost 45. She now only has a little energy for a few hours a day. What is the life expectancy? See answer
Does CVID affect pregnancy? Is there any risk in conceiving, or carrying a baby to full term? See answer
Do you have any information about CVID? How does one contract this disease? Is there any cure or treatment for this disease? My husband has been told he has this disease and has been getting IVIG infusions, but he seems to be getting sicker every time he goes. The last two times he had to have 2 units of red blood. Is this normal? See answer