This table lists symptoms that people with this disease may have. For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. This information comes from a database called the Human Phenotype Ontology (HPO) . The HPO collects information on symptoms that have been described in medical resources. The HPO is updated regularly. Use the HPO ID to access more in-depth information about a symptom.
|Medical Terms||Other Names||
|80%-99% of people have these symptoms|
Impaired gait[ more ]
|Impaired pain sensation||
Decreased pain sensation
Involuntary muscle stiffness, contraction, or spasm
|30%-79% of people have these symptoms|
|5%-29% of people have these symptoms|
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
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My mother has spastic paraplegia. She was diagnosed about five years ago at the Mayo Clinic. She has the complicated form of the disorder because she is confined to a wheelchair and her mind has slowed down. Also, her brother also had this disorder. I know that I have a 50% chance of inheriting this disorder. Since my family members' cases are so severe, does this mean mine probably would be as well? Also, what research is being done to work towards a cure for this? See answer
Can hereditary spastic paraplegia be inherited from grandparent to grandchild (skipping the parent), or is it directly inherited from parent to child only? See answer
I am associated with a hospital in India as a trainee. Recently, we came across a case of Hereditary spastic paraplegia in a patient. We are unaware of the proper genetic testing to be carried out. Is a sample for genetic testing are required? See answer