Some studies suggest that affected people may be at an increased risk for various types of cancer, as well.
The Human Phenotype Ontology (HPO) provides the following list of features that have been reported in people with this condition. Much of the information in the HPO comes from Orphanet, a European rare disease database. If available, the list includes a rough estimate of how common a feature is (its frequency). Frequencies are based on a specific study and may not be representative of all studies. You can use the MedlinePlus Medical Dictionary for definitions of the terms below.
|Signs and Symptoms||Approximate number of patients (when available)|
|Restrictive ventilatory defect||90%|
|Abnormality of temperature regulation||50%|
|Lack of skin elasticity||50%|
|Abnormality of the aortic valve||7.5%|
|Abnormality of the myocardium||7.5%|
|Abnormality of the voice||7.5%|
|Feeding difficulties in infancy||7.5%|
|Recurrent respiratory infections||7.5%|
|Telangiectasia of the skin||7.5%|
Not all patients with antisynthetase antibodies or even those classified as having the antisynthetase syndrome have all manifestations of this syndrome. The syndrome is generally considered present in patients with an antisynthetase antibody plus two of the following features: interstitial lung disease (ILD), inflammatory myopathy, and inflammatory polyarthritis. Also, patients with antisynthetase antibodies generally have more severe myositis and ILD compared with similar conditions.
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
Nonprofit support and advocacy groups bring together patients, families, medical professionals, and researchers. These groups often raise awareness, provide support, and develop patient-centered information. Many are the driving force behind research for better treatments and possible cures. They can direct people to research, resources, and services. Many groups also have experts who serve as medical advisors. Visit their website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD. Suggest an organization to add.
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I have been recently diagnosed with antisynthetase syndrome, acute interstitial lung disease, muscle weakness, skin involvement, scleroderma, and dermatomyositis. Could you please provide me with information on antisynthetase syndrome? I am also interested in learning about prognosis, treatment, and clinical trials. See answer