Atypical hemolytic uremic syndrome differs from a more common condition called typical hemolytic uremic syndrome. The two disorders have different causes and different signs and symptoms.[2]
The Human Phenotype Ontology (HPO) provides the following list of features that have been reported in people with this condition. Much of the information in the HPO comes from Orphanet, a European rare disease database. If available, the list includes a rough estimate of how common a feature is (its frequency). Frequencies are based on a specific study and may not be representative of all studies. You can use the MedlinePlus Medical Dictionary for definitions of the terms below.
| Signs and Symptoms | Approximate number of patients (when available) |
| Abnormal lactate dehydrogenase activity | Very frequent (present in 80%-99% of cases) |
| Acute kidney injury | Very frequent (present in 80%-99% of cases) |
| Hematuria | Very frequent (present in 80%-99% of cases) |
| Microangiopathic |
Very frequent (present in 80%-99% of cases) |
| Very frequent (present in 80%-99% of cases) |
|
| Very frequent (present in 80%-99% of cases) |
|
| Decreased level of thrombomodulin | Frequent (present in 30%-79% of cases) |
| Decreased serum complement factor B | Frequent (present in 30%-79% of cases) |
| Decreased serum complement factor I | Frequent (present in 30%-79% of cases) |
| Anuria | - |
| - | |
| - | |
| Cognitive impairment | - |
| Coma | - |
| Decreased serum complement C3 | - |
| Decreased serum complement factor H | - |
| Diarrhea | - |
| Dysphasia | - |
| Elevated serum creatinine | - |
| Fever | - |
| Hemiparesis | - |
| Hemolytic-uremic syndrome | - |
| Hyperlipidemia | - |
| - | |
| Increased blood urea nitrogen | - |
| Purpura | - |
| Reticulocytosis | - |
| Schistocytosis | - |
| - |
The resources below provide information about treatment options for this condition. If you have questions about which treatment is right for you, talk to your healthcare professional.
Research helps us better understand diseases and can lead to advances in diagnosis and treatment. This section provides resources to help you learn about medical research and ways to get involved.
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Living with a genetic or rare disease can impact the daily lives of patients and families. These resources can help families navigate various aspects of living with a rare disease.
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
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My brother in law has just been diagnosed with atypical hemolytic-uremic syndrome (aHUS) and has suffered kidney failure. We have found out his cousin also has it. One of our concerns is for my husband and our two children. Is there a way that they can be tested to rule out aHUS? See answer
